Novel Approaches in Preventing and Treating Ocular Diseases
ثبت نشده
چکیده
Using a rat lens organ-culture model, the authors investigated whether PM could inhibit AGE formation in the diabetic lens. They measured lens AGEs and relevant biochemical mediators including glutathione and the activities of aldose reductase and glyoxalase in normal and diabetic rat lenses. The results of this study showed that PM failed to block cataract development. However, PM treatment was able to prevent to some extent AGE formation probably by enhancing the activity of aldose reductase and reacting with precursors of AGEs.
منابع مشابه
نگاهی به ژن درمانی، پیشرفتهای اخیر و چشم انداز آینده
Human gene therapy has attracted increasing attention as a highly encouraging therapeutic approach to treat wide variety of diseases, other than genetically inherited and monogenic disorders. This approach entails the introduction and expression of a variety of nucleic acids into human target cells for therapeutic purposes. In this article, we review the history, highlights, recently progresses...
متن کاملPotential Vaccines for Treating Crohn\'s Disease
Crohn's disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) tract and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as Mycobacterium avium paratuberculosis in CD. Apart from different therapeutic approaches for treating CD, developm...
متن کاملمروری بر دستاوردهای اخیر نانوتکنولوژی در رفع چالشهای دارورسانی موضعی به بخشهای قدامی و خلفی چشم: مقاله مروری
Eyes and the vision system allow the human being to receive information from the environment to the extent that 90% of the man’s information is acquired through observation, thus health and correct function of this organ have always been important. Diseases threatening vision such as Acute Macular Degeneration and Diabetic Retinopathy deprive millions of people of seeing every year while acce...
متن کاملRho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow pathway actively regulate conventional outflow resistance was proposed in the 1990s and systematically pursued, exposing novel cellular and molecular mechanisms of intraocular pressure (IOP) regulation. The critical discovery that pharmacologic manipulation of the cytoskeleton of outflow pathway cells dec...
متن کاملClinical Approaches of Retinal Diseases in Pregnancy
Pregnancy leads to significant changes in the body, which potentially affect the retina. Pregnancy can induce disease such as that seen in hypertensive retinopathy and choroidopathy. It can cause exudative retinal detachments in the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP), ...
متن کامل